Publication 117
“Cbl-b mitigates the responsiveness of naive CD8+ T cells that experience extensive tonic T cell receptor signaling”
Joel Eggert, Wendy M. Zinzow- Krame, Yuesong Hu, Elizabeth M. Kolawole, Yuan- Li Tsai, Arthur Weiss, Brian D. Evavold, Khalid Salaita, Christopher D. Scharer, Byron B. Au-Yeung
Science Signaling, volume 17, issue 22
https://doi.org/10.1126/scisignal.adh0439
2024
Publication 116
“Force-Induced Site-Specific Enzymatic Cleavage Probes Reveal That Serial Mechanical Engagement Boosts T Cell Activation”
Jhordan Rogers, Rong Ma, Alexander Foote, Yuesong Hu, and Khalid Salaita
Journal of American Chemical Society (JACS) , volume 146, issue 11, pages 7233–7242
https://doi.org/10.1021/jacs.3c08137
2024
Publication 115
“Molecular Compressive Force Sensor for Mapping Forces at the Cell–Substrate Interface”
Sarah Al Abdullatif, Steven Narum, Yuesong Hu, Jhordan Rogers, Rachel Fitzgerald, and Khalid Salaita
Journal of American Chemical Society (JACS) , volume 146, issue 10, pages 6830–6836
https://doi.org/10.1021/jacs.3c13648
2024
Publication 114
“Simulated microgravity improves maturation of cardiomyocytes derived from human induced pluripotent stem cells”
Parvin Forghani, Aysha Rashid, Lawrence C. Armand, David Wolfson, Rui Liu, Hee Cheol Cho, Joshua T. Maxwell, Hanjoong Jo, Khalid Salaita & Chunhui Xu
Scientific Reports, volume 14, article 2243
https://doi.org/10.1038/s41598-024-52453-1
2024
Publication 113
“An Endosomal Escape Trojan Horse Platform to Improve Cytosolic Delivery of Nucleic Acids”
Steven Narum, Brendan Deal, Hiroaki Ogasawara, Joseph Nicholas Mancuso, Jiahui Zhang, and Khalid Salaita
ACS Nano, available online
https://doi.org/10.1021/acsnano.3c09027
2024
Publication 112
“DNA mechanocapsules for programmable piconewton responsive drug delivery”
Arventh Velusamy, Radhika Sharma, Sk Aysha Rashid, Hiroaki Ogasawara, and Khalid Salaita
Nature Communications, volume 15, article number: 704
https://doi.org/10.1038/s41467-023-44061-w
2024
Publication 111
“Turbo-Charged” DNA Motors with Optimized Sequence Enable Single-Molecule Nucleic Acid Sensing”
Luona Zhang, Selma Piranej, Arshiya Namazi, Steven Narum, and Khalid Salaita
Angewandte Chemie International edition, available online
https://doi.org/10.1002/anie.202316851
2024
Publication 110
“Nanodiscoidal Nucleic Acids for Gene Regulation”
Radhika Sharma, Steven Narum, Shuhong Liu, Yixiao Dong, Kyung In Baek, Hanjoong Jo, and Khalid Salaita
ACS Chemical Biology, available online
https://doi.org/10.1021/acschembio.3c00038
2023
Publication 109
“Heteromultivalency enables enhanced detection of nucleic acid mutations”
Brendan R. Deal, Rong Ma, Steven Narum, Hiroaki Ogasawara, Yuxin Duan, James T. Kindt, and Khalid Salaita
Nature Chemistry, available online
https://doi.org/10.1038/s41557-023-01345-4
2023
Publication 108
“Molecular mechanocytometry using tension-activated cell tagging”
Rong Ma, Sk Aysha Rashid, Arventh Velusamy, Brendan R. Deal, Wenchun Chen, Brian Petrich, Renhao Li, Khalid Salaita
Nature Methods, available online
https://doi.org/10.1038/s41592-023-02030-7
2023
Publication 107
“Optomechanically Actuated Hydrogel Platform for Cell Stimulation with Spatial and Temporal Resolution”
Allison N. Ramey-Ward, Yixiao Dong, Jin Yang, Hiroaki Ogasawara, Elizabeth C. Bremer-Sai, Olga Brazhkina, Christian Franck, Michael Davis, and Khalid Salaita
ACS Biomater. Sci. Eng., volume 9, issue 9, pages 5361–5375
https://doi.org/10.1021/acsbiomaterials.3c00516
2023
Publication 106
“Force Triggered Self-destructive Hydrogels”
Tharindu Rajasooriya, Hiroaki Ogasawara, Yixiao Dong, Joseph Nicholas Mancuso, Khalid Salaita
Advanced Materials, available online
https://doi.org/10.1002/adma.202305544
2023
Publication 105
“Detection of cellular traction forces via the force-triggered Cas12a-mediated catalytic cleavage of a fluorogenic reporter strand”
Yuxin Duan, Fania Szlam, Yuesong Hu, Wenchun Chen, Renhao Li, Yonggang Ke, Roman Sniecinski, Khalid Salaita
Nature Biomedical Engineering, volume 7, pages 1404–1418
https://doi.org/10.1038/s41551-023-01114-1
2023
Publication 104
“All-Covalent Nuclease-Resistant and Hydrogel-Tethered DNA Hairpin Probes Map pN Cell Traction Forces”
Sk Aysha Rashid, Yixiao Dong, Hiroaki Ogasawara, Maia Vierengel, Mark Edoho Essien, Khalid Salaita
ACS Applied Materials & Interfaces, volume 15, issue 28, pages 33362–33372
https://doi.org/10.1021/acsami.3c04826
2023
Publication 103
“Polarized focal adhesion kinase activity within a focal adhesion during cell migration”
Xiaoquan Li, Joseph Dale Combs III, Khalid Salaita, Xiaokun Shu
Nature Chemical Biology, available online
https://doi.org/10.1038/s41589-023-01353-y
2023
Publication 102
“DNA Nanotechnology for Investigating Mechanical Signaling in the Immune System”
Yuesong Hu, Yuxin Duan, Khalid Salaita
Angewandte Chemie, available online
https://doi.org/10.1002/anie.202302967
2023
Publication 101
“Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity”
Mitchell S. Wang, Yuesong Hu, Elisa E. Sanchez, Xihe Xie, Nathan H. Roy, Miguel de Jesus, Benjamin Y. Winer, Elizabeth A. Zale, Weiyang Jin, Chirag Sachar, Joanne H. Lee, Yeonsun Hong, Minsoo Kim, Lance C. Kam, Khalid Salaita & Morgan Huse
Nature Communications, volume 13, article number: 3222
2022
Publication 100
“Mechanotransduction at the Cell Surface and Methods to Study Receptor Forces”
Rong Ma, Brendan R. Deal and Khalid Salaita
Material-based Mechanobiology from Biomaterials Science Series, Royal Society of Chemistry
eISBN: 978-1-83916-185-8
2022
Publication 99
“Adhesive dynamics simulations of highly polyvalent DNA motors”
Aaron T. Blanchard, Selma Piranej, Victor Pan, Khalid Salaita
The Journal of Physical Chemistry B, volume 126, issue 39, pages 7495–7509
2022
Publication 98
“Chemical-to-mechanical molecular computation using DNA-based motors with onboard logic”
Selma Piranej, Alisina Bazrafshan, and Khalid Salaita
Nature Nanotechnology, volume 17, pages 514–523
2022
Publication 97
“DNA Tension Probes Show that Cardiomyocyte Maturation Is Sensitive to the Piconewton Traction Forces Transmitted by Integrins”
Sk Aysha Rashid, Aaron T. Blanchard, J. Dale Combs, Natasha Fernandez, Yixiao Dong, Hee Cheol Cho, and Khalid Salaita
ACS Nano, volume 16, issue 4, pages 5335–534
2022
Publication 96
“Imaging vesicle formation dynamics supports the flexible model of clathrin-mediated endocytosis”
Tomasz J. Nawara, Yancey D. Williams, Tejeshwar C. Rao, Yuesong Hu, Elizabeth Sztul, Khalid Salaita, and Alexa L. Mattheyses
Nature Communications, volume 13, article number 1732
2022
Publication 95
“Molecular Force Sensors”
Rachel L. Bender & Khalid Salaita
American Chemical Society (ACS In Focus)
eISBN: 9780841299177, DOI: 10.1021/acsinfocus.7e4008
2022
Publication 94
“ST6Gal-I-mediated sialylation of the epidermal growth factor receptor modulates cell mechanics and enhances invasion”
Tejeshwar C. Rao, Reena R. Beggs, Katherine E. Ankenbauer, Jihye Hwang, Victor Pui-Yan Ma, Khalid Salaita, Susan L. Bellis, and Alexa L. Mattheyses
Journal of Biological Chemistry, volume 298, issue 4, article 101726
2022
Publication 93
“Gene Regulation Using Nanodiscs Modified with HIF-1-α Antisense Oligonucleotides”
Radhika Sharma, Yixiao Dong, Yuesong Hu, Victor Pui-Yan Ma, and Khalid Salaita
Bioconjugate Chemistry, volume 33, issue 2, pages 279–293
2022
Publication 92
“The magnitude of LFA-1/ICAM-1 forces fine tune TCR-triggered T cell activation”
Victor Pui-Yan Ma, Yuesong Hu, Anna V. Kellner, Joshua M. Brockman, Arventh Velusamy, Aaron T. Blanchard, Brian D. Evavold, Ronen Alon, and Khalid Salaita
Science Advances, volume 8, issue 8
2021
Publication 91
“Supramolecular DNA Photonic Hydrogels for On-Demand Control of Coloration with High Spatial and Temporal Resolution”
Yixiao Dong, J. Dale Combs, Cong Cao, Eric R. Weeks, Alisina Bazrafshan, SK Aysha Rashid, and Khalid Salaita
Nano Letters, volume 21, issue 23, pages 9958–9965
2021
Publication 90
"Massively parallelized molecular force manipulation with on demand thermal and optical control"
Hanquan Su, Joshua Brockman, Yuxin Duan, Navoneel Sen, Hemani Chhabra, Alisina Bazrafshan, Aaron Blanchard, Travis Meyer, Brooke Andrews, Jonathan Doye, Yonggang Ke, Brian R. Dyer, and Khalid Salaita
Journal of the American Chemical Society, volume 143, issue 46, pages 19466–19473
2021
Publication 89
“Conditional Antisense Oligonucleotide Triggered by miRNA”
Jiahui Zhang, Radhika Sharma, Kitae Ryu, Patrick Shen, Khalid Salaita, Hanjoong Jo
ACS Chemical Biology, volume 16, issue 11, pages 2255–2267
2021
Publication 88
“Carfilzomib Treatment Causes Molecular and Functional Alterations of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes”
Parvin Forghani, Aysha Rashid, Fangxu Sun, Rui Liu, Dong Li, Megan R. Lee, Hyun Hwang, Joshua T. Maxwell, Anant Mandawat, Ronghu Wu, Khalid Salaita, and Chunhui Xu
Journal of the American Heart Association, 0:e022247
2021
Publication 87
“An Outside-In Swtich in Integrin Signaling Caused by Chemical and Mechanical Signals in Reactive Astrocytes”
Leonardo A. Pérez, Aysha Rashid, J. Dale Combs, Pascal Schneider, Andrés Rodríguez, Khalid Salaita and Lisette Leyton
Frontiers in Cell and Developmental Biology, volume 9, article 712627
2021
Publication 86
“Mechanically-triggered Hybridization Chain Reaction”
Yuxin Duan, Roxanne Glazier, Alisina Bazrafshan, Yuesong Hu, Sk Aysha Rashid, Brian Petrich, Yonggang Ke, and Khalid Salaita
Angewandte Chemie, 60, 19974-19981
2021
Publication 85
“Turn-key super-resolution mapping of cell receptor force orientation and magnitude using a commercial structured illumination microscope”
Aaron Blanchard, J. Dale Combs, Joshua Brockman, Anna Kellner, Roxanne Glazier, Hanquan Su, Rachel Bender, Alisina Bazrafshan, Wenchun Chen, M. Edward Quach, Renhao Li, Alexa Mattheyses, and Khalid Salaita
Nature Communications, volume 12, article number 4693
2021
Publication 84
“DNA-based microparticle tension sensors (µTS) for measuring cell mechanics in non-planar geometries and for high-throughput quantification”
Yuesong Hu, Victor Pui-Yan Ma, Rong Ma, Wenchun Chen, Yuxin Duan, Roxanne Glazier, Brian G. Petrich, Renhao Li, and Khalid Salaita
Angewandte Chemie, 60, 2-9
2021
Publication 83
“DNA Gold Nanoparticle Motors Demonstrate Processive Motion with Bursts of Speed Up to 50 nm Per Second”
Alisina Bazrafshan, Maria-Eleni Kyriazi, Brandon Alexander Holt, Wenxiao Deng, Selma Piranej, Hanquan Su, Yuesong Hu, Afaf H. El-Sagheer, Tom Brown, Gabriel A. Kwong, Antonios G. Kanaras, and Khalid Salaita
ACS Nano, vol. 15 (5), pg. 8427–8438
2021
Publication 82
“Smart Nucleic Acids as Future Therapeutics”
Jiahui Zhang and Khalid Salaita
Trends in Biotechnology, in press
2021
Publication 81
“DNA Tension Probes to Map the Transient Piconewton Receptor Forces by Immune Cells”
Rong Ma, Anna V. Kellner, Yuesong Hu, Brendan R. Deal, Aaron T. Blanchard, Khalid Salaita
Journal of Visualized Experiments, 169, e62348
2021
Publication 80
“Multivalent molecular tension probes as anisotropic mechanosensors: concept and simulation”
Aaron T Blanchard and Khalid Salaita
Physical Biology, vol. 18 (3), 034001
2021
Publication 79
“Programmable mechanically active hydrogel-based materials”
Yixiao Dong*, Allison N. Ramey-Ward*, and Khalid Salaita
Advanced Materials, 2006600
2021
Publication 78
“Live-cell super-resolved PAINT imaging of piconewton cellular traction forces”
Joshua M. Brockman, Hanquan Su, Aaron T. Blanchard, Yuxin Duan, Travis Meyer, M. Edward Quach, Roxanne Glazier, Alisina Bazrafshan, Rachel L. Bender, Anna V. Kellner, Hiroaki Ogasawara, Rong Ma, Florian Schueder, Brian G. Petrich, Ralf Jungmann, Renhao Li, Alexa L. Mattheyses, Yonggang Ke & Khalid Salaita
Nature Methods, volume 17, pages 1018–1024
2020
Publication 77
“Spectroscopic Analysis of a Library of DNA Tension Probes for Mapping Cellular Forces at Fluid Interfaces”
Roxanne Glazier, Pushkar Shinde, Hiroaki Ogasawara, Khalid Salaita
ACS Applied Materials & Interfaces, vol. 13 (2), pg. 2145–2164
2021
Publication 76
“Conditional Deoxyribozyme-Nanoparticle Conjugates for miRNA-Triggered Gene Regulation”
Jiahui Zhang, Rong Ma, Aaron Blanchard, Jessica Petree, Hanjoong Jo, and Khalid Salaita
ACS Applied Materials & Interfaces, vol. 12 (34), pg. 37851–37861
2020
Publication 75
"Mechanical stimulation of adhesion receptors using light-responsive nanoparticle actuators enhances myogenesis"
Ramey-Ward, Allison; Su, Hanquan; Salaita, Khalid
ACS Applied Materials & Interfaces, vol. 12 (32), pg. 35903–35917
2020
Publication 74
“Engineering DNA-Functionalized Nanostructures to Bind Nucleic Acid Targets Heteromultivalently with Enhanced Avidity”
Deal, Brendan; Ma, Rong; Ma, Victor Pui-Yan; Su, Hanquan; Kindt, James; Salaita, Khalid
Journal of the American Chemical Society, vol. 142 (21), pg. 9653–9660
2020
Publication 73
“Optical Control of Cytokine Signaling via Bioinspired, Polymer-Induced Latency”
Perdue, Lacey; Do, Priscilla; David, Camille; Chyong, Andrew; Kellner, Anna; Ruggieri, Amanda; Kim, Hye Ryong; Salaita, Khalid; Lesinski, Gregory; Porter, Christopher; Dreaden, Erik
Biomacromolecules, vol. 21 (7), pg. 2635–2644
2020
Publication 72
"EGFR activation attenuates the mechanical threshold for integrin tension and focal adhesion formation"
Tejeshwar C. Rao, Victor Pui-Yan Ma, Aaron Blanchard, Tara M. Urner, Shreya Grandhi, Khalid Salaita and Alexa L. Mattheyses
Journal of Cell Science, 133, jcs238840. doi:10.1242/jcs.238840
2020
Publication 71
“Tunable DNA Origami Motors Translocate Ballistically Over μm Distances at nm/s Speeds”
Alisina Bazrafshan, Travis A. Meyer, Hanquan Su, Joshua M. Brockman, Aaron, T. Blanchard, Selma Piranej, Yonggang Ke, Khalid Salaita
Angewandte Chemie, 95, 9514-9521
2020
Publication 70
“Variable Incidence Angle Linear Dichroism (VALiD): a technique for unique 3D orientation measurement of fluorescent ensembles”
Aaron Blanchard, Joshua Brockman, Khalid Salaita, and Alexa Mattheyses
Optics Express, Vol. 28, Issue 7, pp. 10039-10061
2020
Publication 69
“Forces during cellular uptake of viruses and nanoparticles at the ventral side”
Tina Wiegand, Marta Fratini, Felix Frey, Klaus Yserentant, Yang Liu, Eva Weber, Kornelia Galior, Julia Ohmes, Felix Braun, Dirk-Peter Herten, Steeve Boulant, Ulrich S. Schwarz, Khalid Salaita, E. Ada Cavalcanti-Adam & Joachim P. Spatz
Nature Communications, vol.11, Article number: 32
2020
Publication 68
“Super-Resolution Fluorescence Imaging Reveals That Serine Incorporator Protein 5 Inhibits Human Immunodeficiency Virus Fusion by Disrupting Envelope Glycoprotein Clusters”
Yen-Cheng Chen, Chetan Sood, Mariana Marin, Jesse Aaron, Enrico Gratton, Khalid Salaita, and Gregory B. Melikyan
ACS Nano, 14, 9, 10929-10943
2020