Publication 52

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"Mapping the 3D Orientation of Piconewton Integrin Traction Forces"

Joshua M. Brockman, Aaron T. Blanchard, Victor Pui-Yan Ma, Wallace D. Derricotte, Yun Zhang, Meredith E. Fay, Wilbur A. Lam, Francesco A. Evangelista, Alexa L. Mattheyses*, Khalid Salaita*

Nature Methods

2017 (in press)

 

Publication 51

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"Platelet integrins exhibit anisotropic mechanosensing and harness pN forces to mediate platelet aggregation"

Yun Zhang, Yongzhi Qiu, Aaron T Blanchard, Yuan Chang, Joshua M Brockman, Victor Pui-Yan Ma, Wilbur A Lam and Khalid Salaita*

Proceedings of the National Academy of Sciences

2017 (in press)

 

 

Publication 50

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"Site-Selective RNA Splicing Nanozyme: DNAzyme and RtcB Conjugates on a Gold Nanoparticle"

Jessica R. Petree, Kevin Yehl, Kornelia Galior, Roxanne Glazier, Brendan Deal, and Khalid Salaita*

ACS Chemical Biology

2017 (in press)

Publication 49

"Molecular Tension Probes for Imaging Forces at the Cell Surface"

Yang Liu, Kornelia Galior, Victor Pui-Yan Ma, and Khalid Salaita*

Accounts of Chemical Research

2017 (in press)

 

Publication 48

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Supported Lipid Bilayer Platforms to Probe Cell Mechanobiology
Biochimica et Biophysica Acta (BBA) Biomembranes, 2017, S0005-2736(17)30158-X.
PMID: 28502789
Glazier, R.; Salaita, K.  DOI:10.1016/j.bbamem.2017.05.005  

    


Publication 47

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Image-guided genomics of phenotypically heterogeneous populations reveals vascular signaling during symbiotic collective cancer invasion
Nature Communications2017, 8, 15078. PMID: 28497793
Konen, J.; Summerbell, E.; Dwivedi, B.; Galior, K.; Hou, Y.; Rusnak, L.; Chen, A.; Saltz, J; Zhou, W.; Boise, L.; Vertino, P.; Cooper, L.; Salaita, K.; Kowalski, J.; Marcus, A.

 


Publication 46

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DNA-based Nanoparticle Tension Sensors Reveal that T-cell Receptors Transmit Defined pN Forces to Their Antigens for Enhanced Fidelity
Proceedings of the National Academy of Sciences,  vol. 113 no. 20, 5610–5615. 2016.
Yang Liu, Lori Blanchfield, Victor Pui-Yan Ma, Rakieb Andargachew, Kornelia Galior, Zheng Liu, Brian Evavold, Khalid Salaita

Chemical & Engineering News highlight, May 16th 2016, vol. 94 (2), pg. 12, “T cells tug on antigens” 
Interview explaining work  
T cells use handshakes to sort friends from foes


Publication 45

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The Mechanically-induced Catalytic Amplification Reaction for Readout of Receptor-Mediated Cellular Forces
Angewandte Chemie International Edition, 55(18), 5488-5492 2016.
Ma, P.-Y., Victor; Liu, Yang; Yehl, Kevin; Gailor, Kornelia; Zhang, Yun; and Salaita, Khalid

See also Nature Methods (June 2016) highlight “PCR for cellular forces” [pdf]

 


Publication 44

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Ratiometric tension probes for mapping receptor forces and clustering at intermembrane junctions
Nano Letters vol. 16 (7), 4552–4559 2016.
Victor Ma, Victor Pui-Yan; Liu, Yang; Blanchfield, Lori; Su, Hanquan; Evavold, Brian; and Salaita, Khalid

 


Publication 43

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A General Approach for Generating Fluorescent Probes to Visualize Piconewton Forces at the Cell Surface”
Journal of the American Chemical Society, 138 (9), 2901-2904, 2016
Chang, Yuan; Liu, Zheng; Zhang, Yun; Galior, Kornelia; Yang, Jeffery; Salaita, Khalid

[SI Movie 1] [SI Movie 2]

 


Publication 42

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Knockdown of TNF-α by DNAzyme gold nanoparticles as an anti-inflammatory therapy for myocardial infarction
Biomaterials, 83, 12–22. 2016.
Somasuntharam, I.; Yehl, K.; Carroll, S.; Maxwell, J.; Martinez, M.; Pao-Lin Che; Brown, B.; Salaita K.

 


Publication 41

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Nanoscale Optomechanical Actuators for Controlling Mechanotransduction in Living Cell
Nature Methods, 13, 143–146, 2016.
Zheng Liu; Yang Liu; Yuan Chang;  Hamid Reza Seyf; Asegun Henry; Alexa L. Mattheyses; Kevin Yehl; Yun Zhang; Zhuangqun Huang; Khalid Salaita

 


Publication 40

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High-speed DNA-based rolling motors powered by RNase H”,
Nature Nanotechnology, 11, 184–190 2016.
Kevin Yehl; Andrew Mugler; Skanda Vivek; Yang Liu; Yun Zhang; Mengzhen Fan; Eric Weeks; Khalid Salaita

Royal Society of ChemistryPhys.orgNanoWerkEmory Science CommonsVideo

 

 


Publication 39

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Real-time fluorescence imaging with 20 nm axial resolution
Nature Communications, 6, 8307, 2015.
Daniel Stabley; Thomas Oh; Sanford M. Simon; Alexa L. Mattheyses; Khalid Salaita 

 


Publication 38

Titin-based Nanoparticle Tension Sensors Map High-Magnitude Integrin Forces within Focal Adhesions
Nano Letters, 16 (1), pp 341–348 2015.
Galior, Kornelia; Liu, Yang; Yehl, Kevin; Vivek, Skanda, Salaita, K.

See also F1000 prime, [NCBI Link]

 

Publication 37

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Lighting up the Force: Investigating Mechanisms of Mechanotransduction Using Fluorescent Tension Probes
Molecular and Cellular Biology, in press, 2015.
Jurchenko, Carol; Salaita, Khalid

 


Publication 36

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DNA-based Digital Tension Probes Reveal Early Cell Adhesion Mechanics at the Single Molecule Level
Nature Communications, 5, 5167, 2014.
Zhang, Y.; Ge, C.; Zhu, C.; Salaita, K.

[SI movie 1] [SI movie 2] [SI movie 3] [SI movie 4].

See research feature in Nature Reviews Molecular and Cell Biology See research feature in Nature Methods See research feature in C&E News See research feature in Emory eScienceCommons


Publication 35

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Nanoparticle Tension Probes Patterned at the Nanoscale: Impact of integrin clustering on force transmission
Nano Letters, 14(10), 5539-5546, 2014
Liu, Y.; Medda, R.; Liu, Z.; Galior, K.; Yehl, K.; Cavalcanti-Adam, A. E.; Spatz, J.; Salaita, K.,

[SI movie 1] [SI movie 2] [SI movie 3]

 

 


Publication 34

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Integrin-generated Forces Lead to Streptavidin-Biotin Unbinding in Cellular Adhesions
Biophysical Journal, 106(7), 1436-1446, 2014.
Jurchenko, Carol; Chang, Yuan; Narui, Yoshie; Zhang, Yun; Salaita, Khalid 

[SI movie 1] [SI movie 2].

See highlight in April 7th, 2014 issue of C&E News: http://cen.acs.org/articles/92/i14/Cellular-TugWar.html

 

 


Publication 33

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Structurally Defined Nano-scale Sheets from Self-Assembly of Collagen-Mimetic Peptides
Journal of the American Chemical Society, 136(11), 4300-4308, 2014.
Jiang, T.; Xu, C.; Liu, Y.; Liu, Z.; Wall S. J.; Zuo, X.; Lian, T.; Salaita, K.; Ni, C.; Pochan, D.; Conticello, V., P.


Publication 32

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Quantum dots encapsulated within phospholipid membranes: phase-dependent structure, photostability, and site-selective functionalization
Journal of the American Chemical Society, 136(5), 1992–1999, 2014.
Zheng, Weiwei; Liu, Yang; West, Ana; Schuler, Erin; Yehl, Kevin; Dyer, R.; Kindt, James; Salaita, Khalid

 [SI movie 1

 


Publication 31

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The modulation of cardiac progenitor cell function by hydrogel-dependent Notch1 activation
Biomaterials, 35(28), 8103-8112, 2014.
Boopathy, A. V.; Che, P. L.; Somasuntharam I., Fiore V. F.; Cabigas, E. B.; Ban, K.; Brown M. E.; Narui, Y.; Barker T. H.; Yoon, Y.; Salaita, K.; García, A. J.; Davis, M. E.

 


Publication 30

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Membrane Tethered Delta Activates Notch and Reveals a Role for Spatio-Mechanical Regulation of the Signaling Pathway
Biophysical Journal, 105(12), 2655-2665, 2013.
Narui, Y.; Salaita, K.

[SI movie 1] [SI movie 2]

 

 


Publication 29

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Tension Sensing Nanoparticles for Mechano-imaging at the Living Non-living Interface
Journal of the American Chemical Society, 135(14), 5320–5323, 2013.
Liu, Y.; Yehl, K.; Narui, Y.; Salaita, K.

 [movie 1] [movie 2]

 

Publication 28

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Manipulating the Lateral Diffusion of Surface-Anchored EGF Demonstrates that Receptor Clustering Modulates Phosphorylation Levels
Integrative Biology, 5, 659-668, 2013.
Stabley, D.; Retterer, S.; Marshall, S.; Salaita, K.

[movie 1] [movie 2] [movie 3]

 

 


Publication 27

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Visualizing Mechanical Tension Across Membrane Receptors with a Fluorescent Sensor
Nature Methods, 9, 64-67, 2012.
Stabley, D.; Schumacher, C.; Marshall, S.; Salaita, K.

See interview in Nature Methods[nmeth.1816.pdf]

See also C&E news highlight: [C&ENews] [C&E News video]

[youtube]


Publication 26

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Catalytic Deoxyribozyme-Modified Nanoparticles for RNAi-Independent Gene Regulation
ACS Nano, 6(10), 9150–9157, 2012.
Yehl, K.; Joshi, J.P.; Greene, B.L.; Dyer, R. B.; Nahta, R.; Salaita, K.

 

 


Publication 25

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The Molecular Boat: A Hands-on Experiment to Demonstrate the Forces Applied to Self-Assembled Monolayers at Interfaces
Journal of Chemical Education, 89(12), 1547–1550, 2012.
Chan, C.; Salaita, K. 

 

 


Publication 24

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Dip-pen Nanolithography of Optically Transparent Cationic Polymers to Manipulate Spatial Organization of Proteolipid Membranes"
Chemical Science, 3, 794-799, 2012.
Narui, Y.; Salaita, K.

 

 


Publication 23

L-Ala-g-D-Glu-meso-DAP interacts directly with the leucine-rich region domain of nucleotide-binding oligomerization domain 1, increasing the phosphorylation activity of receptor-interacting serine/threonine-protein kinase 2 and its interaction with nucleotide-binding oligomerization domain 1
Journal of Biological Chemistry, 286, 31003-31013, 2011.
Laroui, H.; Yan, Y.; Narui, Y.; Ingersoll, S. A.; Ayyadurai, S.; Charania, M. A.; Zhou, F.; Salaita, K. ; Sitaraman, S.V.; Merlin, D.

 


Publication 22

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Nanomedicine in GI
Physiol. Gastrointest. Liver. Physiol., 300(3), G371-G383, 2011.
Laroui, H.; Wilson, D.S.; Dalmasso G.; Salaita, K.; Murthy, N.; Sitaraman, S.V.; Merlin, D.; Am. J.

 

 

Past Publications

21.

Investigating the Role of Receptor Organization Using Geometrically Patterned Lipid Membranes
Nature Protocols, 6 , 523-539, 2011.
Nair, P. N.; Salaita, K.; Petit, R. P.; Groves, J. T.;

[link][pdf]

20.

Roles of the cytoskeleton in regulating EphA2 signals
Communicative & Integrative Biology, 3(5), 454-457, 2010.
Salaita, K.; Groves, J.T.;

[link][pdf]

19.

Restriction of Receptor Movement Alters Cellular Response: Physical Force Sensing by EphA2
Science, 327(5971), 1380-1385, 2010.
Salaita, K.*; Nair, P.N.*; Petit, R.; Das, D.; Gray, J.W.; Groves, J.T.;

[link][pdf][Science][nature materials][Nature Reviews Molecular Cell Biology][Science Signaling]

18.

The Effects of Organic Vapor on Alkanethiol Deposition Via Dip-Pen
Nanolithography,Scanning, 32 (1); 9-14, 2010.
Salaita, K.; Amarnath, A.; Higgins, T. B.; Mirkin, C. A.;,

[link]

17.

Electrostatic Imaging of DNA Microarrays Using Charged Particles
Nature Biotechnology, 26(7); 825-830, 2008.
Clack, N. C.*; Salaita, K.*; Groves, J. T.;

[link][Chemical and Engineering News] [Nature Materials]

16.

Applications of Dip-Pen Nanolithography
Nature Nanotechnology, 2; 145-155, 2007.
Salaita, K.; Wang, Y.; Vega, R. A.; Mirkin, C. A.;

[link]

15.

DPN-Generated Nanostructures as Positive Resists For Preparing Lithographic Masters or Hole Arrays
Nano Lett, , (6)11; 2493-2498, 2006.
Salaita, K.; Lee, S.-W.; Ginger, D. S; Mirkin, C. A.;

[link]

14.

Massively Parallel Dip-Pen Nanolithography with 55,000 Two-Dimensional Arrays
Salaita, K.
*; Wang, Y.*; Fragala, J.; Vega, R. A.; Liu, C.; Mirkin, C. A.;

Angew. Chem. Int. Edit., 45(43); 7220-7223. (Cover Article), 2006.

[link][Nature][Science][Chemical and Engineering News]

 

13.

Probing Electrochemical Potential Versus Surface Distance by Molecular Orientation
J. Phys. Chem. B., 110(37); 18151-18153 ,2006
Sun, P.; Zong, H.; Salaita, K.; Ketter, J. B.; Hoffman, B. M.; Mirkin, C. A.;

[link]

12.

Metallomacrocycles Incorporating Cofacially Aligned Diimide Units
Chem. Asian J., 2006, 1(5); 686-692. (Cover Article)
Khoshbin, M. S.; Ovchinnikov, M. V., Salaita, K., Mirkin, C. A., Stern, C. L., Zakharov, L. N. Rheingold, A. L.;. 

[link]

11.

Nanopatterns of Biological Molecules. In Nanobiotechnology II: Concept, Applications and Perspectives
Wiley-VCH, Weinheim, Germany, Chapter 13, 235-262, 2007.
Vega, R. A.; Salaita, K.; Kakkessery, J. J.; Mirkin, C. A.;

[link]

10.

Biologically Active Protein Nanoarrays Generated Using Parallel Dip-Pen
Lee, S. W.; Oh, B. K.; Sanedrin, R. G.; Salaita, K.; Mirkin, C. A.
Nanolithography. Adv. Mat2006, 18, 1133-1136.

[link]

9.

Fabrication of Colloidal Nanostructures from Nanolithographically Defined Templates
Interface, 14(4); 58-59, 2005.
Salaita, K.

 

8.

Sub-100nm, Centimeter-Scale, Parallel Dip-Pen
Nanolithography, Small, 1(10); 940-945, 2005.
Salaita, K.
; Lee, S.-W.; Wang, X.; Huang, L.; Dellinger, T. M.; Liu, C.; Mirkin, C. A.

[link]

7.

Spontaneous “Phase Separation” of Patterned Binary Alkanethiol Mixtures
J. Am. Chem. Soc, 127(32); 11283-11287, 2005.
Salaita,K.; Amarnath, A.; Maspoch, D.; Higgins, T. B.; Mirkin, C. A.

[link]

6.

Nanoarrays of Single Virus Particles
Angew. Chem. Int. Edit. 44(37); 6013-6015, 2005.
Vega, R. A.; Maspoch D.; Salaita, K.; Mirkin C. A.

[link] 

5.

The Controlled Evolution of a Single Crystal
Science, 307; 1763-1766, 2005,.
Liu, X.; Zhang, Y.; Goswami, D. K.; Okasinski, J. S.; Salaita, K.; Sun, P.; Bedzyk, M. B.; Mirkin, C. A.

[link]

4.

Surface-Bound Porphyrazines: Controlling Reduction Potentials of Self-Assembled Monolayers Through Molecular Proximity/Orientation to a Metal Surface
J. Am. Chem. Soc., 126(50); 16653-16658, 2004.
esper, B. J.; Salaita K.; Zong, Z.; Mirkin, C. A.; Barrett, A. G.; Hoffman, B. M.

[link][Science]

3.

Size and Temperature Dependence of Surface Plasmon Absorption of Gold Nanoparticles Induced by Tris(2,2'-bipyridine)ruthenium(II)
J. Phys. Chem. B. 108(40); 15543-15551, 2004.
Xu, X.-H. N.; Huang, S.; Brownlow, W.; Salaita, K.; Jeffers, R. B.

[link]

2.

A Massively Parallel Electrochemical Approach to the Miniaturization of Organic Micro- and Nanostructures on Surfaces.
Langmuir, 20(3); 962-968, 2004
Zhang, Y.*;Salaita, K.*; Lim. J.-H.; Lee, K.-B.; Mirkin, C. A.

[link]

1.

Electrochemical Whittling of Organic Nanostructures
Nano Lett. 2(12);1389-1392, 2002.
Zhang, Y.; Salaita, K.; Lim, J.-H.; Mirkin, C. A.

[link]